Scientists in the United States are creating so-called ‘human-pig chimeras’ which will be capable of growing the much-needed organs. While politicians wring their hands about sensible solutions to the shortage, including the nudge of opt-out donation, scientists using genetic manipulations have been making significant progress in growing transplantable organs inside pigs. A lucrative trade in organs has grown up, and transplant tourism has become relatively common. For example, 3,000 kidney transplants were made last year in the United Kingdom, but that still left 5,000 people on the waiting list at the end of the period. This material may not be published, broadcast, rewritten or redistributed.There is a well-documented organ shortage throughout the world. Inside Life Science: Once Upon a Stem CellĬopyright 2016 LiveScience, a Purch company.The oldest woman to have fetal cells in her brain was 94 years old, suggesting that these cells can sometimes stay in the body for a lifetime. They found 63 percent of these women had traces of male DNA from fetal cells in their brains. In a 2012 study, researchers analyzed the brains of 59 women ages 32 to 101, after they had died. In some cases, fetal cells may stay in a woman's body for years. The researchers knew that the cells were from the fetus, and not from the mother, because the cells contained a Y chromosome (found only in males) and the women had all been carrying sons. The study found that the women had fetal cells in all of these tissues. The researchers tested tissue samples from the kidneys, livers, spleens, lungs, hearts, and brains of 26 women who tragically died while pregnant or within one month of giving birth. This can happen when a woman becomes pregnant, and a small number of cells from the fetus migrate into her blood and travel to different organs.Ī 2015 study suggested that this happens in almost all pregnant women, at least temporarily. More commonly, people may exhibit so-called microchimerism-when a small fraction of their cells are from someone else. A blood transfusion will also temporarily give a person cells from someone else, but in a bone marrow transplant, the new blood cells are permanent, according to the Tech Museum of Innovation in San Jose, California. But in other cases, the recipient may have a mix of both their own blood cells and donor ones, according to a 2004 review paper in the journal Bone Marrow Transplantation. In some cases, all of the blood cells in a person who received a bone marrow transplant will match the DNA of their donor. This means that a person with a bone marrow transplant will have blood cells, for the rest of their life, that are genetically identical to those of the donor, and are not genetically the same as the other cells in their own body. Bone marrow contains stem cells that develop into red blood cells. During such transplants, which can be used for example to treat leukemia, a person will have their own bone marrow destroyed and replaced with bone marrow from another person. The mystery was solved when doctors discovered that Keegan was a chimera-she had a different set of DNA in her blood cells compared to the other tissues in her body.Ī person can also be a chimera if they undergo a bone marrow transplant. But the tests suggested that genetically, Keegan could not be the mother of her sons. For example, in 2002, news outlets reported the story of a woman named Karen Keegan, who needed a kidney transplant and underwent genetic testing along with her family, to see if a family member could donate one to her. These individuals often don't know they are a chimera. The remaining fetus will have two sets of cells, its own original set, plus the one from its twin. This can occur with fraternal twins, if one embryo dies very early in pregnancy, and some of its cells are "absorbed" by the other twin. One way that chimeras can happen naturally in humans is that a fetus can absorb its twin. But chimeras aren't always man-made-and there are a number of examples of human chimeras that already exist.Ī chimera is essentially a single organism that's made up of cells from two or more "individuals"-that is, it contains two sets of DNA, with the code to make two separate organisms. The news that researchers want to create human-animal chimeras has generated controversy recently, and may conjure up ideas about Frankenstein-ish experiments.
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